| 4th Regiment South Carolina Volunteer Infantry (African Descent) | |
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South Carolina state flag |
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| Active | July, 1863-March 14, 1864 |
| Country | United States |
| Allegiance | United States of America Union |
| Branch | Infantry |
The 4th Regiment South Carolina Volunteer Infantry (African Descent) was an African-American infantry regiment that served in the Union Army during the American Civil War.
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The 4th South Carolina Infantry was organized at Fernandina, Florida and mustered into Federal service in July, 1863.
The regiment was consolidated with 3rd South Carolina to form the 21st United States Colored Infantry Regiment on March 14, 1864.